陈路

1.职称：研究员、优秀青年 3.      研究方向：运用生物信息学的方法结合分子生物学技术研究疾病的发生机制；致力于研究可变剪接在干细胞分化、癌症等疾病发生等方面的作用机理。 4.      邮件：luchen@scu.edu.cn 5.      个人经历： 2011年6月－ 2016年8月博士后经历 (剑桥大学，桑格研究所，英国)     2008年10月－ 2011年6月博士学位 (巴斯大学,  英国)       6.      代表性论文： （1）Chen L, Bing G, Casale F P et al. 2016. Genetic driversof epigenetic and transcriptional variation in human immune cells. Cell (inpress) （2）Astle WJ, Elding H, Jiang T et al. (including Chen L). 2016. Thousands ofgenetic variants modulate blood cell variation and function in humans. Cell (inpress) （3）Iotchkova V, Huang J, Morris JA et al. (includingChen L).2016.Discovery andrefinement of genetic loci associated with cardiome-x-tabolic risk using denseimputation maps. Nature genetics doi:10.1038/ng.3668. （4）Polfus L M, Khajuria R K, Schick U M et al.(including Chen L). Whole-Exome Sequencing Identifies Loci Associated withBlood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants inHuman Hematopoiesis. The American Journal of Human Genetics.99(2), 481-488 （5）The UK10K Consortium (including Chen L). 2015.The UK10K project: rare variants in health and disease. Nature 526 (7571): 82-90 （6）Vasquez L, Mann L A, Chen L, Soranzo N. 2015. From GWAS to function: lessons fromblood cells. ISBT Science Series (0), 1–9 （7）Tovar-Corona JM, Castillo-Morales A, Chen L et al. 2015. Alternativesplice in alternative lice. Molecular biology and evolution, 32(10), 2749-2759 （8）ChenL,Kostadima M, Martens JH et al. 2014. Transcriptional diversity during lineagecommitment of human blood progenitors. Science345(6204): 1251033.(Highlightedin NatureReviews Genetics). （9）ChenL, Bush SJ, Tovar-Corona JMet al. 2014. Correcting forDifferential Transcript Coverage Reveals a Strong Relationship betweenAlternative Splicing and Organism Complexity. Molecular biology and evolution31(6): 1402-1413. （10）Shin SY, Fauman EB, Petersen AK (including Chen L) et al. 2014. An atlas ofgenetic influences on human blood me-x-tabolites. Nature genetics 46(

运用生物信息学的方法结合分子生物学技术研究疾病的发生机制；致力于研究可变剪接在干细胞分化、癌症等疾病发生等方面的作用机理。